Among genes regulated by NME1-EVs or NME2-EVs in our dataset, which showed a significant change in expression and are known to be involved in processes of tumour progression, the following ones were selected for further analysis: MMP7 (matrix-metalloproteinase 7) and COL5A3 (collagen type V alpha 3 chain), which are related to metastasis/invasion, were significantly overexpressed; in addition, CHI3L1 (chitinase 3-like 1) also showed an increase in expression in fibroblasts after NME1- or NME2-EV treatments (Figure 4A,B). The gene discussed is CHI3L1; the disease is neoplasm.