This elevated IL6 level was associated with the activation of the JAK2/STAT3 signaling cascade and increased levels of SRY-Box transcription factor 2 (SOX2), Nanog homeobox (Nanog), ALDH1A1, and ATP-binding cassette subfamily G member 2 (ABCG2) genes in breast cancer cells in vitro and in vivo [119], which was completely prevented by blocking the cellular IL6 signaling [119]. Here, STAT3 is linked to breast cancer.