These approaches revealed that most of the described cancer hallmark signaling pathways were significantly upregulated in triple-negative breast cancer with a highly enriched CAF population. BGN, a soluble secreted protein, was upregulated in CAFs compared to normal cancer-adjacent fibroblasts (NAFs). The expression was negatively associated with CD8+ T cells and poor prognostic outcomes. This evidence concerns the gene CD8A and triple-negative breast carcinoma.