SMO and breast cancer: Resistin, another adipokine with an increased secretion in obese adipose tissue [206], was highly associated with the transcription of pluripotency genes such as aldehyde dehydrogenase 1 family member A1 (ALDH1A1), ITGA4, protein lin-28 homolog B (LIN28B), smoothened homolog (SMO), and sirtuin 1 (SIRT1) in low malignant breast cancer cells and non-carcinogenic breast epithelial cells [207].