The interaction with cancer cells increased the release of tumor-promoting cytokines such as CCLs, CXCLs, SDF, and EGF [105,117]; angiogenesis factors including VEGF, angiopoietins, EGF, galectin-1, IGF1, and keratinocyte growth factor (KGF) [102,115,118,144]; and EMT inducers such as TGFβ, platelet-derived growth factor D (PDGF-D), and stem cell factor (SCF) [106,118,145]. Here, IGF1 is linked to cancer.