In general, CAFs shape the tumor microenvironment by the production of proinflammatory cytokines, including IL-1β and IL-6 [21,120], and express the ligands CXCL12 [30], CXCL1 [121], and G-CSF [122] that can drive downstream immunosuppressive signaling pathways. This evidence concerns the gene CXCL12 and neoplasm.