VEGFA and breast carcinoma: The 48 h exposure of breast carcinoma (MCF-7) to dichloromethane (DCM) extracts of C. sativa samples with IC50 values < 50 μg/mL, the two DCM extracts of two C. sativa L. samples (DTP-06 and DTP-13) reduced extracellular vascular endothelial growth factor (VEGF) level significantly [175].