SOS1 and chronic myelogenous leukemia, BCR-ABL1 positive: In contrast, the profiles of the SOS1-KO transgenic mice of the same age showed an almost complete abolition of the development of all the pathological alterations typical of CML and displayed rather normal levels of WBC, HB, and platelets or the relative percentage of the different granulocytic and lymphocytic subpopulations (Figure 3A red, upper).