Indeed, a pie chart representation of the percentage distribution of the different granulocytic and lymphocytic populations present in the peripheral blood of 7-month-old and 9-month-old animals (Figure 3C) provides clear visual evidence of the dramatic increase in the ratio of neutrophils/lymphocytes (blue/orange sectors, Figure 3C) that is a typical hallmark of CML progression, which was almost completely reverted in the SOS1-KO mice in comparison with their counterparts, openly diseased WT and SOS2-KO p210BCR/ABL transgenic mice (Figure 3C). This evidence concerns the gene SOS2 and chronic myelogenous leukemia, BCR-ABL1 positive.