Interestingly, the comparison of the Kaplan–Meier survival curves of WT, SOS1-KO, or SOS2-KO transgenic mice expressing p210BCR/ABL showed that the single ablation of SOS1 or SOS2 extended the lifespan and survival of the CML-diseased transgenic mice in comparison with WT transgenic animals expressing normal levels of both GEFs (Figure 2). Here, SOS2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.