SOS2 and chronic myelogenous leukemia, BCR-ABL1 positive: Furthermore, our unsupervised computational analysis of the genomic data available in the CRISPR dataset of the Cancer Dependency Map portal [48,49,50] for multiple cancer and blood lineage cell lines, has assigned SOS1 (but not SOS2) the highest dependency score (dp score = −1.26) of CML cell lines in the database (Figure 6).