SOS2 and chronic myelogenous leukemia, BCR-ABL1 positive: The TAM treatment (to induce SOS1 ablation) of appropriate strains from our p210BCR/ABL|SOS1/2-KO mouse colony allowed us to generate SOS1-KO, SOS2-KO, and WT adult, transgenic mice, which were used to evaluate the effect of single SOS1 or SOS2 genetic ablation on the lifespan and survival curves of mice suffering CML caused by their endogenously expressed p210BCR/ABL transgene (Figure 2).