SOS2 and chronic myelogenous leukemia, BCR-ABL1 positive: Consistent with these views, we also observed that SOS1 ablation (but not SOS2 ablation) caused a very dramatic reversal of various typical hematological CML-related pathological alterations [33] involving different peripheral blood cell populations as well as internal organs relevant for hematopoiesis, such as the spleen or the liver.