It is worth mentioning that apoptotic GBM cells induced proliferation and therapy resistance of surviving tumor cells by secreting apoptotic extracellular vesicles (apoEVs) enriched with RNA binding motif protein 11 (RBM11) to switches splicing of MDM4 and Cyclin D1 toward the expression of more oncogenic isoforms [107]. The gene discussed is RBM11; the disease is glioblastoma.