MDM4 and glioblastoma: It is worth mentioning that apoptotic GBM cells induced proliferation and therapy resistance of surviving tumor cells by secreting apoptotic extracellular vesicles (apoEVs) enriched with RNA binding motif protein 11 (RBM11) to switches splicing of MDM4 and Cyclin D1 toward the expression of more oncogenic isoforms [107].