As observed for the U373 GBM cell line, cholesterol dysregulation was supported by the upregulation of several cholesterol-related transcripts, including HMGCS1, HMGCR, MVK, DHCR24 and DHCR (Figure 2B and Figure S2B,C), consistent with the enrichment of the GO term cholesterol biosynthetic process (Table 1). The gene discussed is MVK; the disease is glioblastoma.