HMGCR and glioblastoma: As observed for the U373 GBM cell line, cholesterol dysregulation was supported by the upregulation of several cholesterol-related transcripts, including HMGCS1, HMGCR, MVK, DHCR24 and DHCR (Figure 2B and Figure S2B,C), consistent with the enrichment of the GO term cholesterol biosynthetic process (Table 1).