Moreover, the percentage of activated CD4 T lymphocytes, which was determined by evaluating those expressing the MHC class 2 membrane receptor (the Human Leukocyte Antigen DR isotype—HLA-DR,), is observed to be significantly less active in the tumor microenvironment than those present in fibroadenomas (Figure 3F,G and Figure 4E and Table 2). The gene discussed is CD4; the disease is neoplasm.