Primary GO_KEGG pathways enriched were ECM-receptor interaction (FDR: 1.44 × 10−19), proteoglycans in cancer (FDR: 1.26 × 10−15), focal adhesion (FDR: 1.26 × 10−15), and PI3K-Akt signaling pathway (FDR: 1.26 × 10−15). The gene discussed is PIK3CA; the disease is cancer.