PCSK9 and Hyperglycemia: Additionally, DAG1 (dystroglycan 1) increased secretion leads to Hippo pathway and PKC cascade activation in response to hyperglycemia, whilst over-secretion and activation of LDLR leads to receptor internalization and subsequent PCSK9 overexpression and SRBP1, Insig-Srebp-Scap, pathway activation., which is a recognisedmetastasis driver in colorectal cancer.