Here, we have presented the first BC secretome integrative and comparatice analysis and identified putative predictors of DCIS to IDC (TGFβ1, DAG1, LGALSBP3, and LOXL2) as well as grade I and II IDC to grade III IDC (LGALS3BP, LAMB1-3, LAMC2, BMP1, AGRN, EGFR, COL7A, FBN1, and GPC1) progression. Here, LOXL2 is linked to ductal breast carcinoma in situ.