CD8A and neoplasm: Notably, combining anti-PD-1 antibody and cMn-MOF@CM with ultrasound irradiation showed a long-term systemic anti-tumor immune response, confirmed by increasing the frequency of matured DCs, as well as the infiltration of activated CD8+ CD69+, CD8+ granzyme B+, CD8+ IFN-γ+ and OVA-specific CD8+ T cells preventing tumor growth and recurrence [110].