Additionally, combining the mentioned nanovaccine with thermo-responsive, curcumin-loaded polymer NPs (a self-assembled hydrogel) in 4T1 models augmented the systemic host T cell immune responses by improving CD8+ T cell infiltration at the site of the tumor, attenuating the recurrence of local tumor, and inhibiting metastasis to the lungs [111]. The gene discussed is CD8A; the disease is neoplasm.