STAT3 and neoplasm: Moreover, STAT3 not only contributes functionally to promoting tumor cell proliferation, survival, invasion, angiogenesis, and immune evasion, but it has been recently indicated to play crucial roles in the inflammation associated with tumorigenesis, obesity and metabolic syndrome, the cancer stemness pathway, and premetastatic niche formation [11,12,27,28,29,30,31,32].