The ablation of STAT3 in hematopoietic cell lineages facilitates antitumor immunity to inhibit tumor proliferation and metastasis via enhancing the functions of CD8+ T cells, natural killer (NK) cells, dendritic cells, and neutrophils in a murine model of melanoma, suggesting that STAT3 signaling may suppress tumor immune surveillance systems [148]. This evidence concerns the gene STAT3 and melanoma.