Mutations in receptor tyrosine kinases, such as EGFR, and Src family proteins have been associated with the constitutive activation of STAT3 in NSCLC [133,134], and STAT3 activation has been associated with lymph node metastasis and clinical stage progression and is an independent prognostic factor of NSCLC [135,136]. The gene discussed is STAT3; the disease is metastatic malignant neoplasm in the lymph nodes.