Notably, a mouse model of acute colitis bearing the Y757F point mutation in murine gp130 (gp130Y757F/Y757F), which abrogates the SOCS3- and/or SHIP2-mediated negative feedback loop of the IL-6/STAT3 signal, resulting in the hyperactivation of STAT3 and has been shown to be resistant to colorectal damage and weight loss. The gene discussed is STAT3; the disease is colitis.