Subsequently, it has been demonstrated that IL-11/STAT3-mediated signaling functions as a stronger promoter of the progression of sporadic and inflammation-associated CRC than IL-6/STAT3 signaling in the progression of sporadic and inflammation-associated CRC progression, suggesting that IL-11/STAT3 signaling is a promising therapeutic target for the cure of CRCs [70,74]. Here, IL11 is linked to colorectal carcinoma.