We previously performed a series of studies analyzing the roles of signal-transducing adaptor protein-2 (STAP-2) in the proliferation of several types of cancer cells via acting as an adaptor molecule that modulates STAT3 activity [33] and recently found that AT-rich interactive domain-containing protein 5A (ARID5A) functions as an RNA-binding molecule that stabilizes mRNAs such as those of indoleamine 2,3-dioxygenase 1 (IDO1), C-C motif chemokine ligand 2 (CCL2), and STAT3, resulting in the induction of an immunosuppressive TME in malignant tumors [34]. The gene discussed is STAP2; the disease is cancer.