SESN2 and hydrops fetalis: Here, mice fed a HF chow diet and with an overexpression of Sesn2 (tTa-tet-Sesn2) present in their cardiomyocytes were more protected from weight gain compared to their wildtype littermates (tet-Sesn2), Sesn2flox/flox, and cSesn2−/− mice (Figure 2).