SESN2 and hydrops fetalis: However, as expected, mice that were fed the HF diet gained weight at a more rapid pace and, on average, weighed more at the experimental endpoint (weight at endpoint: Sesn2flox/flox NC: 28.6 ± 3.9 g; Sesn2flox/flox HF: 34.0 ± 3.4 g; cSesn2−/− NC: 26.7 ± 5.5 g; cSesn2−/− HF: 32.6 ± 5.9 g; tet-Sesn2 NC: 21.8 ± 0.9 g; tet-Sesn2 HF: 42.1 ± 5.8 g; tTa-tet-Sesn2 NC: 28.5 ± 6.4 g; tTa-tet-Sesn2 HF: 38.0 ± 3.9 g; mean ± SD).