Although, we do see an opposite pattern occurring between Sesn2flox/flox mice and tet-Sesn2 mice—tet-Sesn2 has a mild upregulation of Nrf2 under a HF diet while Sesn2flox/flox has a mild downregulation of Nrf2 under the same condition. The gene discussed is NFE2L2; the disease is hydrops fetalis.