GRM7 and Pain: With regard to mGluR7, another group found that an mGluR7 PAM (AMN082) inhibited glial reactivity and decreased pro-inflammatory cytokine release in paclitaxel-induced acute neuropathic pain; this inhibition of the spinal glial reaction alleviated mechanical and thermal hypersensitivity in neuropathic rats, providing further support for a neuroimmune role of mGluR signaling in pain pathogenesis [162].