PRKN and Parkinson disease: In a familial form of PD, mutations have been identified in genes encoding mitochondrion-associated proteins such as mitochondrial phosphatase and tensin homologue (PTEN)-induced kinase 1 (PINK1), Parkinson juvenile disease protein 2 (parkin), protein deglycase DJ-1 (Parkinson disease protein 7), and coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) [197].