Among innate immune cells, monocytes and macrophages are essential for the initiation of sepsis, as they release various proinflammatory cytokines and chemokines, TNFα, IL-6, MCP-1 and intercellular adhesion molecule 1 (ICAM-1), which can cause kidney damage and SAKI, resulting in a high mortality rate. This evidence concerns the gene ICAM1 and Nephropathy.