Neutrophils infiltrate renal tissue under chemotactic signals generated by chemokines and cytokines, including C-X-C motif chemokine ligand 1 (CXCL1), MCP-1, and interleukin-17A (IL-17A), which are released by activated macrophages, DCs and T cells during AKI. This evidence concerns the gene CXCL1 and acute kidney injury.