The recent study by Yao et al. [88] in CLP-induced SAKI also demonstrated that during the early stage of sepsis, M1 macrophage infiltration and production of proinflammatory cytokines–IL-6 and TNF-α was observed in renal tissues and was inhibited by the application of the macrophage infiltration inhibitor heparin. This evidence concerns the gene IL6 and Sepsis.