Among all ribosomal proteins found up- or down-regulated in different pathologic conditions, including AD [13], RACK1 emerges as an interesting player due to its pivotal roles in both physiological and pathological conditions and in different cellular settings, including the immune system [88,89,90,91,92], several cancer types [93,94,95,96,97,98], and in the neuronal context [99,100,101,102,103,104]. Here, RACK1 is linked to Alzheimer disease.