GFAP expression was not increased within the retina after an intravitreal injection of either naïve exosomes (1 day) or ALS-exosomes (7 days), suggesting that intravitreal injection of naïve or ASL-modified exosomes did not induce an immediate reactive retinal gliosis (Figure 7). The gene discussed is GFAP; the disease is amyotrophic lateral sclerosis.