Cytoplasmic aggregation of TDP-43 represents a pathological hallmark of many neurodegenerative diseases, including AD, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, and limbic predominant age-related TDP-43 encephalopathy, indicating that vitamin B12 is a possibly beneficial therapeutical micronutrient for several neurodegenerative diseases. The gene discussed is TARDBP; the disease is neurodegenerative disease.