Instead, González-Mariscal et al. highlighted (i) the structural similarity between ZO-2 and a known tumour suppressor protein in Drosophilia, (ii) the targeting of ZO-2 by viral oncogenic proteins in animal models and (iii) the role of ZO-2 as a transcriptional repressor of certain genes involved in cell proliferation as possible evidence for a tumour suppressor effect [75]. This evidence concerns the gene TJP2 and neoplasm.