Finally, three genes implicated in rare cholestatic disorders will be discussed in relation to the development of HCC, focusing in particular on bile acid-induced damage (due to ATP-binding cassette subfamily B member 11, or ABCB11, changes), disruption of intercellular junction formation (due to tight junction protein 2, or TJP2, changes) and disruption of cell polarity (due to vacuolar protein sorting-associated protein 33B, or VPS33B, changes). This evidence concerns the gene VPS33B and hepatocellular carcinoma.