TJP2 and hepatocellular carcinoma: For instance, Wei et al. described a family in which five siblings who were homozygous for the same TJP2 mutation showed variable degrees of liver disease; for instance, one sibling developed HCC at the age of 23, one sibling developed acute-on-chronic liver failure at the age of 36 without evidence of HCC, one sibling developed severe intrahepatic cholestasis of pregnancy and two other siblings showed elevated liver enzymes at the ages of 19 and 25 without evidence of chronic liver disease at the time [81].