We transduced the non-Treg CD4+ T cell leukemia cell line, E6 Jurkat cells, with lentivirus made from an IL37 overexpressing vector (IL37 OE) and demonstrated the induction of Treg-like phenotype and function in IL37 OE Jurkat cells, compatible to human primary Treg cells. This evidence concerns the gene CD4 and T-cell leukemia.