After the addition of MaR1, it was found that the expression of NRF2 in the whole cells and nuclei was significantly higher in the osteoblasts treated with a T2DM medium compared to the T2DM group, proving that MaR1 improved the expression of NRF2 overall and encouraged its transfer into the nucleus (Figure 2C,D). The gene discussed is NFE2L2; the disease is type 2 diabetes mellitus.