In summary, we found that the combination of antibodies against IRF2 with antibodies against CD14, CD38, or CD86 helped to distinguish proinflammatory Ly6Chi monocytes from both infection models, supporting the results of the transcriptome study (Figure 3C) in that these monocytes are already in a transitional stage to anti-inflammatory monocytes. The gene discussed is IRF2; the disease is infection.