Moreover, IDE knockout (KO) mice display hyperinsulinemia, hyperglycemia, insulin and glucose intolerance, increased body mass and reduced levels of insulin receptors, as well as accumulation of endogenous Aβ [14,15,16].Importantly, human genetic studies have pinpointed the IDE region of Chr 10 with both T2DM and AD [16,17,18]. Here, INS is linked to type 2 diabetes mellitus.