IFNG and neoplasm: Namely, ATRA in combination with TMZ enhanced TMZ effects on malignant behavior of GBM cells [419], in combination with interferon-gamma (IFN-γ), it induced apoptosis of GBM cell lines [404], and in combination with taxol, paclitaxel or IFN-γ, it induced differentiation, apoptosis and reduction in tumor volume of xenografts of GBM cell lines [420,421,422].