A phase III clinical trial CENTRIC (NCT00689221) was conducted to determine overall survival as well as efficacy and safety of cilengitide in combination with standard chemoradiotherapy, compared to standard treatment alone, in newly diagnosed GBM patients with methylated O6-methylguanine-DNA-methyltransferase (MGMT) gene promoter. The gene discussed is MGMT; the disease is glioblastoma.