Opačak-Bernardi and co-workers have developed conjugate of dnMAML peptide, thermo-responsive elastin-like polypeptide (for targeted delivery to tumor cells) and cell penetrating peptide (for enhanced cellular uptake and BBB penetration) which was efficiently delivered to GBM cells, causing cell cycle arrest, apoptosis and downregulation of Notch target genes Hes-1 and Hey-L [229]. Here, HES1 is linked to glioblastoma.