NOTCH1 and glioblastoma: Antibodies targeting Notch1 (Brontictuzumab, OMP-52M51; NCT01778439), Notch2/Notch3 (Tarextumab, OMP-59R5; NCT01277146) and DLL4 (Enoticumab, REGN421, NCT00187159; Demcizumab, OMP-21M18, NCT00744563) have been tested in phase I trials in patients with solid tumors; however, no GBM patients were included.