Targeting of key signaling pathways found deregulated in GBM, such as EGFR, PDGFR, PI3K–PTEN-Akt-mTOR, cell cycle-associated pathways (CDK4/6, CDKN2A/B), P53, pRB, RAS/MAPK, and STAT3, has been previously described in detail (reviewed in [11,24,25,26]). Here, AKT1 is linked to glioblastoma.