CALR and neoplasm: Likewise, the vaccination of mice with a replication-deficient adenovirus vector expressing calreticulin-HPV16 E7 fusion protein induced a stronger E7-specific immune response, inhibited tumor growth in pre-vaccinated mice xenografted with E7-expressing TC-1 cells, generating long-term memory against E7 and in established tumors resulted in complete tumor regression in all animals [219].