Previous studies reported that semaphorins members play important regulatory roles in the development of the nervous system (Sema3A, 3F, 4D, 6C, 6D, 7A), immune system (Sema4D), reproductive systems (Sema3), cancer progression (Sema3A, 4D, 6D) and the vascular system (Sema3A, 3E, 4D, 6D) [36,37,38,39,40]. The gene discussed is SEMA4D; the disease is cancer.