Corroborating the tumor-suppressive function of fibroblasts in pancreatic cancer, loss of pancreatic fibroblasts in Pft1acre/+; KrasLSL-G12D/+; Tgfbr2fl/fl; aSMA-tk mice that develop PDAC while losing myofibroblasts when treated with ganciclovir showed accelerated tumor growth, more undifferentiated tumor histology, and worse survival [158]. Here, TKT is linked to neoplasm.