A closer examination of the murine rhabdomyosarcomas from the CAGGS-CreER; R26-SmoM2 mice suggested that they more closely resembled fetal rhabdomyoma histologically than aggressive rhabdomyosarcomas with upregulation of Gli1 and Ptch1 mRNA transcription, indicative of Hh pathway activation [61]. The gene discussed is PTCH1; the disease is rhabdomyoma.