PTCH1 and urothelial carcinoma: Interest in the relationship between Hh signaling pathway and bladder cancer arose in the late 1990s when urothelial carcinomas were determined to have loss of heterozygosity deletions (LOH) on chromosome 9q, which includes the region encoding for PTCH1, hinting that the Hh pathway may support urothelial carcinoma proliferation [138,139,140,141].