LncRNA SNHG1, which is upregulated in PD, sequesters miR-221/222 and indirectly regulates p27/mammalian target of rapamycin (mTOR) as well as microtubule associated proteins 1A/1B light chain 3B (LC-III) autophagic regulator expressions to inhibit autophagy, while promoting neuronal cytotoxicity in PD [209]. This evidence concerns the gene CDKN1B and Parkinson disease.