LncRNAs SNHG6 and SNAI3-AS1 bind to UPF1 and recruit it to the mRNA that codes for the protein known as small mothers against decapentaplegic homolog 7 (SMAD7) and enables the degradation of SMAD7 mRNA in hepatocellular carcinoma via the NMD process. This evidence concerns the gene SMAD7 and hepatocellular carcinoma.