The LncRNA UCA1, which is upregulated in gastric cancers, recruits EZH2 (enhancer of zeste homolog 2) to the promoters of the genes that encode p27 (CDKN1B) and the sprouty RTK signaling antagonist 1 (SPRY1) to mediate the repressive H3K27me3-trimethylation. The gene discussed is UCA1; the disease is gastric cancer.