RRM2 and cancer: In hepatocellular carcinoma, the elevated levels of linc-NMR has been reported to interact with Y-box binding protein 1 (YBX1) and regulate the enzymes in pyrimidine metabolism such as ribonucleotide reductase regulatory subunit M2 (RRM2), thymidylate synthetase (TYMS), and thymidine kinase 1 (TK1) to enhance the deoxynucleotide triphosphate availability, favoring cancer cell proliferation [135].