The formation of endocytic vacuoles is the earliest form of vacuolisation in the acinar cells subjected to inducers of acute pancreatitis taurolithocholic acid 3-sulfate (TLC-S) or a high concentration of CCK [9,109]; these vacuoles are clearly resolvable within 3 min from the beginning of the stimulation and remain the dominant form of cytosolic vacuoles for at least 1 h [9,109]. The gene discussed is CCK; the disease is acute pancreatitis.