PNPLA3 and obesity due to melanocortin 4 receptor deficiency: The most common predisposing factors for NAFLD are male sex, age > 50 years, hyperlipidemia, obesity, insulin resistance and T2DM, and a lack of physical exercise as well as genetic polymorphisms (e.g., patatin-like phospholipase domain-containing 3 (PNPLA3) I148M polymorphism) [9,17,18,19].