In fact, several inflammatory markers, such as C-reactive protein (CRP), IL-6, monocyte chemotactic protein 1 (MCP-1), and TNF-α, have been found to be elevated in patients with NAFLD and even more exacerbated in patients with NASH compared to healthy controls, independent of obesity and other confounding factors. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.