Especially, HSPB8, a known target of both HSF1 and ERα, but also other known HSF1 targets (HSPD1, HSPA4L) were not upregulated in ER−/HSF1high breast cancers (Figure 6A; see also Figure S8 showing the correlation analyses between HSF1 and HSPs expression). The gene discussed is HSPA4L; the disease is breast cancer.