CDH2 and hepatocellular carcinoma: Here, we demonstrate in a large cohort of HCC and HCA patients, as well as respective non-neoplastic/normal livers, that E- and N-cadherin expression constitute a general characteristic of hepatocellular differentiation, and may therefore be used as a diagnostic marker for hepatocellular/liver origin; however, our data do not suggest E- and N-cadherin as suitable markers for EMT in non-neoplastic and neoplastic liver tissue.