By immunohistochemistry, membranous E- and N-cadherin staining was detected at nearly equal amounts in hepatocytes of the normal and cirrhotic liver, FNH, DN, HCA, and HCC (Figure 5), while reduced E- as well as N-cadherin staining was only observed in few higher-grade HCC metastases. The gene discussed is CDH2; the disease is hepatocellular carcinoma.