On the mRNA level in the TCGA cohort, this seems not to apply to catenins); however, it is of note that especially β-catenin has a dual function in AJ and Wnt-signaling cascade and that CTNNB1 is frequently mutated in HCC and some HCA, which leads to Wnt-activation [54,55]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.