Thus, N-cadherin, together with E-cadherin positivity, may be used to differentiate primary liver carcinomas such as HCC and intrahepatic cholangiocarcinoma from liver metastases of extrahepatic primary tumors, such as other gastrointestinal adenocarcinomas positive only for E-cadherin, but not N-cadherin, and may therefore be useful in routine histopathologic diagnostics. This evidence concerns the gene CDH1 and intrahepatic cholangiocarcinoma.