Dominant mutations in HSPB1 are associated with CMT type 2F and distal hereditary motor neuropathy (dHMN) [150]; the S135F mutation leading to a higher affinity of HSPB1 for tubulin overstabilizing microtubules determines neuropathies affecting axonal transport [150]. Here, HSPB1 is linked to distal hereditary motor neuropathy.