Whilst QKI-5 overexpression significantly attenuated heart failure through regulating the expression of specific circular RNAs derived from the from the Titin (Ttn ), Formin homology 2 domain containing 3 (Fhod3 ) and Striatin/calmodulin-binding protein 3 (Strn3 ) genes [99]. Here, FHOD3 is linked to heart failure.