Contrarily, the CM from the CRC cells (HCT116 siCTRL/siKRAS and LS174T siCTRL) led to a downregulation in the expression of MMPs (MMP1, 2 and 3 in HCT116 and MMP2 as well as MMP14 in LS174T) in CCD-18Co fibroblasts. The gene discussed is MMP1; the disease is colorectal carcinoma.