Besides SOAT1, several proteins related to cholesterol homeostasis including CYP7A1 (Rank:16, Cytochrome P450 7A1, located in endoplasmic reticulum), HMGCR (Rank:17, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, located in endoplasmic reticulum) and SREBF2 (Rank:45, Sterol regulatory element-binding protein 2, located in cytoplasm and endoplasmic reticulum) are reported to be significantly up-regulated in the HCC tumour tissue, suggesting these genes might be potential targets for HCC drugs [49] (Supplementary Table S5). This evidence concerns the gene HMGCR and hepatocellular carcinoma.