For example, among the top 80 prioritized Hypercholesterolemia (HP:0003124)-associated genes (only 18 of them are membrane proteins) predicted by GraphPheno, the knockdown of SOAT1 (Sterol O-acyltransferase 1, located in endoplasmic reticulum) (Rank:65) was reported to alter the distribution of cellular cholesterol, and effectively suppresses the proliferation and migration of hepatocellular carcinoma [49]. Here, SOAT1 is linked to familial hypercholesterolemia.