HSP90AA1 and cancer: Furthermore, the hyper-connectedness or rigidity of the chaperome might have profound consequences on the sensitivity of cancer cells to Hsp90 inhibition; a less interconnected proteome means that disturbing Hsp90 function might affect a subset of the regulated network, rendering Hsp90 non-essential, while a hyper-connected “epichaperome” has increased sensitivity towards the inhibition of Hsp90.