We collected and analysed several human studies where the participants were treated with some of these anti-obesity drugs, and changes in body weight and in the levels of TNF-α were reported [29,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179] (Table S9). Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.