Like so, the TNF-α levels were (S) reduced in Chinese adults with T2D with the rare variant −87 T > C of PPARD (p < 0.05, −1.7 and −3.1 pg/mL) [146], in malnourished elderly people with the rare variant of rs769214 of CAT (p < 0.001, −3.2 and −3.9 pg/mL) [153], in patients with heart failure and with the rare genotype for rs1800471 of TGFB (p = 0.042, −7.0 pg/mL) [154], and in healthy individuals with the rare rs2234632 variant of the gene ZIP2 (p = 0.011, −6.1 pg/mL) [155]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.