Parasutterella has been reported to be positively associated with BMI, type 2 diabetes, and low-grade inflammation in obesity revealed by a cohort study [50]; however, although Parasutterella abundance was deceased by the sea buckthorn puree, the plasma inflammatory markers TNF-α and IL-6 were not altered in population with hypercholesterolemia. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.