Although GCS, NIHSS, atrial fibrillation, CRP, diabetes, creatinine and NLR were adjusted in a binary logistic regression model, serum periostin level remained a significant predictor for ASPECT < 6 status on admission (OR, 5.911; CI, 0.990–0.999; p = 0.015, Table 3). This evidence concerns the gene POSTN and atrial fibrillation.