Some blood tests are essential to diagnose PCOS in adolescent and adult women for the exclusion of other disorders that can cause irregular menstrual cycles and/or hyperandrogenism including beta human chorionic gonadotropin hormone (if sexually active), LH, FSH, thyroid function tests, prolactin, midnight salivary cortisol, and 17-hydroxyprogesterone (17-OHP) [79,80]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.