In our study, xerostomia grade 1 was observed in 24.2% of the patients after two cycles of 177Lu-PSMA-I&T/-617, while 40% of the patients reported grade 1 to 2 xerostomia during the long-term follow-up (maximum follow-up of 52 months), receiving up to 61.8 GBq. The gene discussed is FOLH1; the disease is xerostomia.