By constructing a PPI network, we found that USP39, RBM22, SNRPD1, CPSF3, SRSF1, SRSF3, HSPA8, HNRNPU, SRSF4, CWC27, EFTUD2, ALYREF, NCBP2, SNRPA1, and POLR2D may play pivotal roles in the development of HCC. Here, SNRPA1 is linked to hepatocellular carcinoma.