By constructing a PPI network, we found that USP39, RBM22, SNRPD1, CPSF3, SRSF1, SRSF3, HSPA8, HNRNPU, SRSF4, CWC27, EFTUD2, ALYREF, NCBP2, SNRPA1, and POLR2D may play pivotal roles in the development of HCC. The gene discussed is SRSF1; the disease is hepatocellular carcinoma.