By constructing a PPI network, we found that USP39, RBM22, SNRPD1, CPSF3, SRSF1, SRSF3, HSPA8, HNRNPU, SRSF4, CWC27, EFTUD2, ALYREF, NCBP2, SNRPA1, and POLR2D may play pivotal roles in the development of HCC. Here, POLR2D is linked to hepatocellular carcinoma.