In the present study, the results showed that NCBP2 was upregulated in multiple cancers and played a detrimental role at the LIHC stage, and NCBP2 expression was significantly related to another five cancers, including KICH, KIRP, LUAD, PAAD, and PRAD, and was negatively correlated with the over survival of those cancers. The gene discussed is NCBP2; the disease is cancer.