ALYREF and neoplasm: SNRPA1 was reported to promote HCC proliferation through activating the mTOR-signaling pathway [27], and the phosphorylation of SRSF3 by PPM1G could result in the proliferation, invasion, and metastasis of HCC [28]; furthermore, ALYREF was significantly correlated to both advanced tumor-node-metastasis stages and poor HCC prognosis [29], which is similar to our results.