NKX2-5 and coronary artery disorder: In addition to aneuploidies as well as copy number variants (gains and losses), pathogenic variations in over 100 genes, encompassing GATA4, NKX2.5, SOX7, and SOX17, have been implicated with the pathogenesis of CHD [2,4,47,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80].