IL6 and neoplasm: Moreover, they discovered that tumor cells produced growth factors, IL-6, and myeloid cell-attracting chemokines; additionally, they found that in the TME, the majority of infiltrating cells were macrophages with a mixed inflammatory phenotype that expressed receptors to chemokines; myeloid-cell-attracting chemokines; and also receptors for IL-6, IL-10, IL-1, and TNF-α [39].