In contrast to the PanNETs though, paragangliomas are negative for Keratins (e.g., AE1/AE3 or CAM5.2) or CEA with immunochemistry (as they are non-epithelial neoplasms), whereas they exhibit immunopositivity for GATA-3 and tyrosine hydroxylase (TH) [5,36,37,38,39]. The gene discussed is TH; the disease is paraganglioma.