As both vascular endothelial cells and smooth muscle cells prominently express ADM and its receptor, ADM may control vascular functions and may have a role in rheumatic diseases such as Kawasaki disease (KD), Henoch–Schönlein purpura (HSP), acute rheumatic fever (ARF), and Familial Mediterranean Fever (FMF). This evidence concerns the gene ADM and acute kidney injury.