As both vascular endothelial cells and smooth muscle cells prominently express ADM and its receptor, ADM may control vascular functions and may have a role in rheumatic diseases such as Kawasaki disease (KD), Henoch–Schönlein purpura (HSP), acute rheumatic fever (ARF), and Familial Mediterranean Fever (FMF). The gene discussed is ADM; the disease is hereditary spastic paraplegia.