Regarding the behavior of this biomarker in congenital heart disease, it seems that ADM levels may play beneficial roles in reducing increased pulmonary arterial resistance or alleviating hypoxemia in these patients, since its levels are higher in patients with congenital heart disease (CHD) and pulmonary hypertension (PH), and it is positively correlated with pulmonary arterial resistance (Rp). This evidence concerns the gene ADM and congenital heart disease.