Although plasma levels of ADM were increased in pediatric and adult patients with CHF irrespective of the cause [52], a larger study focusing on the pediatric population found an unsatisfactory diagnostic power for MR-proADM regarding general patients with HF and the subset of patients with dilated cardiomyopathy (DCM) [53]; it was, however, negatively correlated with poor left ventricle (LV) function. Here, ADM is linked to hydrops fetalis.