LEP and metabolic dysfunction-associated steatotic liver disease: Recently, the DIRECT PLUS randomized clinical trial verified that a green Mediterranean diet, enriched in specific green polyphenols (Mankai, green tea, and walnuts) and restricted in red and processed meat, led to weight loss, a decline of NAFLD prevalence, and a significant reduction in intrahepatic fat assessed by magnetic resonance, which was associated with a decline in leptin and chemerin plasma levels [135].