Biochemical parameters, including fasting plasma glucose, postprandial glucose, HOMA-IR, hemoglobin A1c, AST, ALT, GGT, TG, and total cholesterol, as well as body weight, BMI, and waist-to-hip ratio, all significantly improved with metformin therapy comparing to the control group; however, liver histologic scores, namely steatosis, ballooning, NAFLD activity score, and fibrosis, did not significantly change after metformin treatment, and lobular inflammation even became worse after therapy [150,151,152,153]. Here, GPT is linked to steatosis.