Furthermore, a randomized single-center study investigating the effects of guided lifestyle changes with endurance activity and nutrition advising or meal replacement with soy protein-based preparation in NASH patients demonstrated the positive correlation of leptin changes with body weight, fat mass, and reduction in waist circumference and total abdominal fat, while adiponectin changes were inversely correlated with these parameters [136]. The gene discussed is LEP; the disease is metabolic dysfunction-associated steatohepatitis.