MCAM and androgen insensitivity syndrome: While this study did not confirm the cellular origin of annexin V+ EVs, a previous study that compared circulating EVs 48 h post AIS to high-cardiovascular-risk controls demonstrated an increase in annexin V+ EVs originating from endothelial cells (CD146+), neural progenitor cells (CD34+, CD56+), platelets (CD61+), erythrocytes (CD235ab+), and leucocytes (CD45+) [93].