ANXA5 and androgen insensitivity syndrome: Previous studies have demonstrated an increase in annexin V+ EVs in ICH patients compared to controls [64,96,97], and even more specifically have demonstrated an increase in endothelial EVs (CD105+, CD106+, CD54+, or CD62E+) along with EVs of other origins [98]; this may not be specific as an increase in endothelial EV release is observed in AIS as well.