It has also been observed that there is a direct correlation between CA II activity and diabetes, in the sense that diabetic patients have higher values of this isoenzyme, while CA I isoenzyme, known for its implications in vasoconstriction and vasodilation, has increased activity in all patients with myocardial infarction, regardless of their diabetic status [30,31,32]. The gene discussed is CA1; the disease is myocardial infarction.